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Search Results for " colon cancer "

ターゲット

155

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天然化合物

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カタログ番号	製品名	別名	ターゲット
T9963	MPT0B390		HDAC
	MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.		HDAC
T8973	HS-1793		Others
	HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model		Others
T2455	PFK-015	PFK15,PFK 015	Glucokinase , Autophagy
	PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).		Glucokinase , Autophagy
T15681	L-161982		Prostaglandin Receptor
	L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice.		Prostaglandin Receptor
T2343	AS601245		JNK
	AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.		JNK
T21331	SAR-020106		Chk
	SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.		Chk
T8500	VLX600		OXPHOS , Mitochondrial Metabolism , Autophagy
	VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.		OXPHOS , Mitochondrial Metabolism , Autophagy
T14779	BRD7389		SGK , FLT , Pim , CDK , S6 Kinase , DAPK
	BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.		SGK , FLT , Pim , CDK , S6 Kinase , DAPK
T10297L	AMG 487		CXCR
	AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.		CXCR
T2345	PTC-209	PTC209,PTC 209	BMI-1 , Autophagy
	PTC-209 is a potent and selective BMI-1 inhibitor.		BMI-1 , Autophagy
T14371	Barasertib	AZD1152	Apoptosis , Aurora Kinase
			Apoptosis , Aurora Kinase
T28410	PHPS1	PHPS-1,PHPS 1	Phosphatase
	PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.		Phosphatase
T0159	Pranoprofen	Pyranoprofen	Apoptosis , COX , PGE Synthase , Prostaglandin Receptor
	Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.		Apoptosis , COX , PGE Synthase , Prostaglandin Receptor
T8545	FEN1-IN-4	FEN1 Inhibitor C2	Others
	FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)		Others
T6609	NMS-E973		HSP
	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.		HSP
T6916	OICR-9429	OICR 9429	Histone Methyltransferase , JAK
	OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemia cells in vitro.		Histone Methyltransferase , JAK
T7698	BS194		CDK
	BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.		CDK
T1520	Aliskiren hemifumarate	CGP 60536,SPP 100,CGP60536B	RAAS , Autophagy
	Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity.		RAAS , Autophagy
T6583	MG-101	ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101	Cysteine Protease , Proteasome
	MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.		Cysteine Protease , Proteasome
T2602	Barasertib-HQPA	1H-Pyrazole-3-acetamide,Barasertib,AZD1152-HQPA,AZD2811,AZD1152-HQPA\|AZD2811	Apoptosis , Aurora Kinase
	Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.		Apoptosis , Aurora Kinase
TQ0157	EIPA	L593754,MH 12-43	Sodium Channel , TRP/TRPV Channel
	EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.		Sodium Channel , TRP/TRPV Channel
T6178	PTC-209 hydrobromide	PTC-209 HBr	BMI-1 , Autophagy
	PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).		BMI-1 , Autophagy
T7351	3-Methylcytidine		Nucleoside Antimetabolite/Analog
	3-Methylcytidine as biomarkers of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.		Nucleoside Antimetabolite/Analog
T31008	Copper probe CF4	Copper probe CF-4,Copper probe CF 4,Copper fluor CF4,CF4 prob
	Copper probe CF4 (Copper fluor CF4) is a fluorescent copper probe that can be used to study colon cancer.
T9544	Compound 1T-0216		Others
	Compound 1T-0216 is a blocker of AKT1-FAK interactions and reduces stimulation of FAK phosphorylation by extracellular stress in human SW620 colon cancer cells without affecting basal FAK phosphorylation.		Others
T67702	MTOR inhibitor 9d		PI3K , mTOR
	mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia, skin cancer, breast cancer, lung cancer and colon cancer.		PI3K , mTOR
T64391	Antiproliferative agent-15		Others
	Antiproliferative agent-15 is a reagent with anticancer activity. Antiproliferative agent-15 showed antiproliferative activity against human colon cancer (HCT116 and HCT15) and brain cancer (LN-229 and GBM-10).		Others
T12000	MEN11467		Neurokinin receptor
			Neurokinin receptor
T77733	TNKS-2-IN-2		Wnt/beta-catenin
	TNKS-2-IN-2 is a novel and potent TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.		Wnt/beta-catenin
T26585	AK301	AK-301,AK 301	Apoptosis , Microtubule Associated
	AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a ...		Apoptosis , Microtubule Associated
T24131	HDAC3-IN-T247	HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247	Histone Demethylase , Antiviral
	HDAC3-IN-T247 (HDAC3 inhibitor T247) is a selective and potent histone deacetylase 3 (HDAC3) inhibitor with anticancer and antiviral activities.HDAC3-IN-T247 induces NF-κB acetylation in human colon cancer HCT116 cells i...		Histone Demethylase , Antiviral
T9545	Compound 1T-0219 (SC)		FAK
	Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 colon cancer cells without affecting basal FAK phosphorylati...		FAK
T6883	Samotolisib	GTPL8918,LY3023414	DNA-PK , PI3K , mTOR , Autophagy
	Samotolisib (LY3023414) is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. Samotolisib (LY3023414) has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, ...		DNA-PK , PI3K , mTOR , Autophagy
T73164	SOS1-IN-15		Raf
	SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.		Raf
T24051	Exisulind	Sulindac sulfone,CP248	Apoptosis , PKA
	Exisulind (CP248) induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth i...		Apoptosis , PKA
T76866	Icrucumab	LY 3012212,IMC-18F1	VEGFR
	Icrucumab ( IMC-18F1) is a humanized IgG1 monoclonal antibody targeting vascular endothelial growth factor receptor-1.Icrucumab has antitumor activity.Icrucumab has been studied in metastatic colon cancer.		VEGFR
T72107	Werner syndrome RecQ helicase-IN-1		DNA/RNA Synthesis
	Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.		DNA/RNA Synthesis
T6345	Tirbanibulin	KX2-391,KX-01	Microtubule Associated , Src
	Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of colon, pancreatic, prostate and breast cancer. It is a substrate-targeted kinase inhibit...		Microtubule Associated , Src
T61318	BRD4 Inhibitor-20		Epigenetic Reader Domain
	BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity. BRD4 Inhibitor-20 has antiproliferative activity in cancer cell lines and is used in studies of various cancers, such as colon canc...		Epigenetic Reader Domain
T25125	AZA197	AZA 197,AZA-197	CDK
	AZA197 (AZA-197) is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.		CDK
T14034	3CAI		Akt
			Akt
T77687	3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one		Others
	3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one shows antitumor activity in a human colon cancer cell line and may be used to combat thrombosis.		Others
T36970	STD1T		DUB
	STD1T is a selective and potent inhibitor of the deubiquitinase USP2a with potential anticancer activity that reduces cell cycle protein D1 protein levels in HCT116 colon and MCF-7 breast cancer cells.		DUB
T30087	Antroquinonol		Reactive Oxygen Species , Nrf2
	Antroquinonol is a ubiquinone derivative from Antrodia camphorata with anti-inflammatory and anticancer activities.Antroquinonol reduces oxidative stress and inhibits inflammation and sclerosis in mice with focal segment...		Reactive Oxygen Species , Nrf2
T24855	TASIN-1 Hydrochloride	TASIN-1 HCl,TASIN 1 HCl,TASIN1 HCl	APC
	TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apopt...		APC
T77651	Tubulin polymerization-IN-47		Microtubule Associated
	Tubulin polymerization-IN-47 is a tubulin polymerization inhibitor and mitotic inhibitor with antitumor activity and inhibitory effects on neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 an...		Microtubule Associated
T76873	Nidanilimab	CAN04	IL Receptor
	Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. Nidanilimab has antitumor activity, cutting off the IL1α and IL1β signaling pathways and inducing the immune system to destr...		IL Receptor
T10883	CRA-026440	PCI-34051	HDAC
			HDAC
T21821L	REV 5901A	REV 5901 HCl,REV 5901A（101910-24-1 Free base）	Leukotriene Receptor , Lipoxygenase , Antibiotic
	REV 5901A (REV 5901 HCl) is an orally active leukotriene receptor antagonist and 5-lipoxygenase inhibitor with antimicrobial activity that attenuates colon cancer growth in mice.REV 5901A has been used in studies of asth...		Leukotriene Receptor , Lipoxygenase , Antibiotic
T25150	BI-69A11	BI 69A11,(E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one	NF-κB , Akt
	BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the susceptibility of colon cancer cells to mda-7/IL-24-induce...		NF-κB , Akt

Compounds

Synonym: PFK15,PFK 015

Target: Glucokinase, Autophagy

L-161982

T15681

Synonym:

Target: Prostaglandin Receptor

Target: OXPHOS, Mitochondrial Metabolism, Autophagy

BRD7389

T14779

Synonym:

Target: SGK, FLT, Pim, CDK, S6 Kinase, DAPK

Synonym: PTC209,PTC 209

Target: BMI-1, Autophagy

Barasertib

T14371

Synonym: AZD1152

Target: Apoptosis, Aurora Kinase

PHPS1

T28410

Synonym: PHPS-1,PHPS 1

Target: Phosphatase

Pranoprofen

T0159

Synonym: Pyranoprofen

Target: Apoptosis, COX, PGE Synthase, Prostaglandin Receptor

FEN1-IN-4

T8545

Synonym: FEN1 Inhibitor C2

Target: Histone Methyltransferase, JAK

Aliskiren hemifumarate

T1520

Synonym: CGP 60536,SPP 100,CGP60536B

Target: RAAS, Autophagy

MG-101

T6583

Synonym: ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101

Target: Cysteine Protease, Proteasome

Barasertib-HQPA

T2602

Synonym: 1H-Pyrazole-3-acetamide,Barasertib,AZD1152-HQPA,AZD2811,AZD1152-HQPA|AZD2811

Target: Apoptosis, Aurora Kinase

EIPA

TQ0157

Synonym: L593754,MH 12-43

Target: Sodium Channel, TRP/TRPV Channel

PTC-209 hydrobromide

T6178

Synonym: PTC-209 HBr

Target: BMI-1, Autophagy

3-Methylcytidine

T7351

Synonym:

Target: Nucleoside Antimetabolite/Analog

Copper probe CF4

T31008

Synonym: Copper probe CF-4,Copper probe CF 4,Copper fluor CF4,CF4 prob

Antiproliferative agent-15

Target: Neurokinin receptor

TNKS-2-IN-2

T77733

Synonym:

Target: Wnt/beta-catenin

AK301

T26585

Synonym: AK-301,AK 301

Target: Apoptosis, Microtubule Associated

HDAC3-IN-T247

T24131

Synonym: HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247

Target: Histone Demethylase, Antiviral

Compound 1T-0219 (SC)

Synonym: GTPL8918,LY3023414

Target: DNA-PK, PI3K, mTOR, Autophagy

Synonym: Sulindac sulfone,CP248

Target: Apoptosis, PKA

Icrucumab

T76866

Synonym: LY 3012212,IMC-18F1

Target: VEGFR

Werner syndrome RecQ helicase-IN-1

T72107

Synonym:

Target: DNA/RNA Synthesis

Tirbanibulin

T6345

Synonym: KX2-391,KX-01

Target: Microtubule Associated, Src

BRD4 Inhibitor-20

T61318

Synonym:

Target: Epigenetic Reader Domain

AZA197

T25125

Synonym: AZA 197,AZA-197

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

Target: Reactive Oxygen Species, Nrf2

TASIN-1 Hydrochloride

T24855

Synonym: TASIN-1 HCl,TASIN 1 HCl,TASIN1 HCl

Target: APC

Tubulin polymerization-IN-47

T77651

Synonym:

Target: Microtubule Associated

Synonym: REV 5901 HCl,REV 5901A（101910-24-1 Free base）

Target: Leukotriene Receptor, Lipoxygenase, Antibiotic

BI-69A11

T25150

Synonym: BI 69A11,(E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one

Target: NF-κB, Akt

カタログ番号	製品名	別名	ターゲット
T3755	Pinostilbene		Others
	Pinostilbene obviously attenuates the phosphorylation of c-Jun and JNK triggered by 6-OHDA.		Others
TN1722	Hamamelitannin		Antifection
	Hamamelitannin has cytotoxic, and antibiofilm activities. It increases the susceptibility of S. aureus to antibiotic treatment in in vivo Caenorhabditis elegans and mouse mammary gland infection models. It also has a hig...		Antifection
TN3967	Epieriocalyxin A		ERK , BCL , ROS , Caspase , DNA/RNA Synthesis , JNK
	Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.		ERK , BCL , ROS , Caspase , DNA/RNA Synthesis , JNK
T5S1133	Ganoderic acid D		Apoptosis , Sirtuin
	1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 micr...		Apoptosis , Sirtuin
T4723	D-Tagatose	D-(-)-Tagatose,d-tagatos	Others , Endogenous Metabolite
	D-Tagatose (D-(-)-Tagatose), a rare natural hexoketose, is an isomer of d-galactose. D-Tagatose occurs naturally in Sterculia setigera gum, and it is also found in small quantities in various foods such as sterilized and...		Others , Endogenous Metabolite
T8160	EGCG Octaacetate		Others , Antibacterial
	EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities.		Others , Antibacterial
T34394	Rotenolone	Rotenolone I,12alpha-HYDROXYROTENONE	Others
	Rotenolone (12alpha-HYDROXYROTENONE) is a metabolite of Rotenone which is a natural compound derived from plants of the genera Derris and Lonchocarpus.		Others
TN7226	2-Hydroxy-3-methoxy chalcone
	2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer.
T5750	Oxyberberine	Ketoberberine,Berlambine,8-Oxoberberine	Others
	Oxyberberine (8-Oxoberberine) is isolated from the methanol extract of A. mexicana. It has been used to study the SW480 human colon cancer cell line.		Others
T3806	Kaempferide	Kaempferol 4'-O-methyl ether,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Influenza Virus , Antibacterial , Autophagy
	kaempferide (4'-Methylkaempferol) inhibits the proliferation of native and estrogen receptor beta overexpressing colon cancer cells through a mechanism not mediated by ligand binding dependent estrogen receptor activatio...
TN1244	3'-Demethylnobiletin		LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis
	3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling ...		LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis
T4S1637	Gamma-Mangostin	Normangostin	Others , 5-HT Receptor
	1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ...		Others , 5-HT Receptor
T4S0590	Columbin		Phospholipase , COX , Parasite
	1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.		Phospholipase , COX , Parasite
T24403	Folinic acid	HSDB 6544,Leucovorin	Endogenous Metabolite , Antifolate
	Folinic acid (Leucovorin) is a biofolic acid that can be used in the treatment of methotrexate, often in combination with Methotrexate (MTX) to reduce MTX-induced toxicity, and can be used as an adjuvant treatment for co...		Endogenous Metabolite , Antifolate
T5S0506	Rotundic acid	Rutundic acid	Apoptosis , Others , p38 MAPK , Akt , mTOR
	Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c...		Apoptosis , Others , p38 MAPK , Akt , mTOR
T2S0265	Robinin	NSC 9222	TLR
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR...		TLR
TN1237	3-O-Methylgallic acid	3,4-Dihydroxy-5-methoxybenzoic acid	Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
	3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may offer protection against colon cancer after its formation ...		Apoptosis , NF-κB , OCT , DNA/RNA Synthesis , STAT
TN2083	Pinostrobin chalcone
	Pinostrobin chalcone, a chalcone analog isolated from the leguminous plant, Mucuna pruriens, exhibits anticancer activity with an IC50 value of 20.42±2.23 μg/mL against MDA-MB-231 and 22.51±0.42 μg/mL against the HT-29 c...
T30969	Clitocine		Apoptosis , BCL
	Clitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activity, inducing the production of p53 protein in cells carryin...		Apoptosis , BCL
T6S1027	Tussilagone		Others
	1. Tussilagone inhibits dendritic cell function through the induction of heme oxygenase-1. 2. Tussilagone has anti-cancer activity, might be a potential chemotherapeutic agent for the prevention and treatment of human co...		Others
T2S2382	3'-Hydroxypterostilbene	3'-HPT	Apoptosis , Autophagy
	3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, b...		Apoptosis , Autophagy
T1660	Silibinin	Silibinin A,Silybin,Silymarin I	Reactive Oxygen Species , Autophagy
	Silibinin (Silybin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin an...		Reactive Oxygen Species , Autophagy
T4672	Brevilin A		Apoptosis , Anti-infection , JAK , STAT , Autophagy
	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...		Apoptosis , Anti-infection , JAK , STAT , Autophagy
T6S0119	Dauricine		Apoptosis , Others , NF-κB
	1. Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. 2. Dauricinec can pass the blood-brain barrier, and that P-glycoprotein has an important ro...		Apoptosis , Others , NF-κB
T37067	9-hydroxy Stearic Acid		HDAC
	9-hydroxy Stearic Acid is a hydroxy fatty acid that is the active metabolite of 9-PAHSA. 9-hydroxy Stearic Acid is formed from 9-PAHSA through carboxyl ester lipase in the liver and pancreas. The 9-hydroxy Stearic Acid (...		HDAC
TN5422	Ciwujiatone
	Ciwujiatone exhibits significant activities against colon cancer cell lines SW480 and SW620.
T23645	Aeroplysinin 1	NSC170364,Aeroplysinin I,NSC 170364,NSC-170364
	Aeroplysinin I is an antibacterial compound from the sponge. It has cytotoxic activity against colon cancer cells by promoting β-catenin degradation.
TN6500	Microgrewiapine A
	Microgrewiapine A is a selective cytotoxic agent for colon cancer cells over normal colon cells and to exhibit nicotinic receptor antagonistic activity for both the hα3β4 and hα4β2 receptor subtypes.
T40708	Neoanhydropodophyllol
	Neoanhydropodophyllol, a cyclolignan derivative, exhibits potent antineoplastic activity by exerting cytotoxic effects on various cancer cell lines including leukemia, lung carcinoma, and colon carcinoma.
TN4352	Jatamanvaltrate B		Others
	Jatamanvaltrate B shows cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8),and hepatoma (Bel7402) cell lines.		Others
TN3495	Benzyl ferulate		TNF , Antifection
	Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE-30 oesophageal squamous cancer, and NCI-N87 gastric carcin...		TNF , Antifection
TN5249	Volvaltrate B		Others
	Volvaltrate B shows cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 uM, r...		Others
TMA1008	Ganoderic acid S		Others
	A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the t...		Others
TN6547	Angustifoline
	Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stim...
TN3646	Chlorovaltrate K		Others
	Chlorovaltrate K shows moderate cytotoxicity against lung adenocarcinoma (A 549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8) and hepatoma (Bel 7402) cell lines with IC50 values of 0.89-9.76 uM.		Others
TN3468	Atractylochromene		Wnt/beta-catenin
	Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.		Wnt/beta-catenin
TN4132	Germanicol
	Germanicol induces selective growth inhibitory effects in human colon HCT-116 and HT29 cancer cells through induction of apoptosis, cell cycle arrest and inhibition of cell migration. Germanicol may have anti-inflammator...
TN1498	Cimigenol		Others
	Cimigenol is a potential antitumor compound, combination of it with an autophagy inhibitor may be a valuable strategy for the chemoprevention or treatment of colon cancer. It exerted potent cytotoxic activity against SMM...		Others
TN3404	Altholactone		BCL , p38 MAPK , ROS , Akt , Caspase , Antifection , p53
	Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of various types of cancer cells through inducing apoptosis vi...		BCL , p38 MAPK , ROS , Akt , Caspase , Antifection , p53
TN3152	6-Acetonyldihydrochelerythrine		ERK , BCL , Akt , HIV Protease , PPAR , p53
	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively...		ERK , BCL , Akt , HIV Protease , PPAR , p53
TN5021	Sikokianin C
	Sikokianin C is a biflavonoid isolated from Wikstroemia sikokiana.Sikokianin C is a selective cystathionine β-synthase inhibitor with antitumour activity for the treatment of human colon cancer.
T38243	Hygrolidin
	Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC...
TN4046	Excisanin A		MMP , FAK , PARP , GSK-3 , NF-κB , Wnt/beta-catenin , Akt , Caspase , PI3K , Prostaglandin Receptor , JNK
	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatm...
TN3070	4beta-Hydroxywithanolide E		PARP , HSP , NF-κB , COX
	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it...		PARP , HSP , NF-κB , COX
T36961	Malformin C
	Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human...
TN5546	Pedaliin	Pedalin,Pedalitin 6-O-glucoside,Glucosyl-6-pedalitin	Antioxidant
	Pedaliin is a flavonoid extracted from the above-ground parts of sesame (Sesamum indicum L) and the Tibetan medicine Dracocephalum tanguticum Maxim.Pedaliin has shown antioxidant and anticancer effects against colon canc...		Antioxidant
TN4291	Isofuranodiene		IL Receptor , NOS
	Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting...		IL Receptor , NOS
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs =...
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Col...

天然物製品

Target: ERK, BCL, ROS, Caspase, DNA/RNA Synthesis, JNK

Ganoderic acid D

T5S1133

Synonym:

Target: Apoptosis, Sirtuin

D-Tagatose

T4723

Synonym: D-(-)-Tagatose,d-tagatos

Target: Others, Endogenous Metabolite

EGCG Octaacetate

T8160

Synonym:

Target: Others, Antibacterial

Rotenolone

T34394

Synonym: Rotenolone I,12alpha-HYDROXYROTENONE

Target: Others

2-Hydroxy-3-methoxy chalcone

Synonym: Ketoberberine,Berlambine,8-Oxoberberine

Target: Others

kaempferide

T3806

Synonym: Kaempferol 4'-O-methyl ether,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Influenza Virus, Antibacterial, Autophagy

3'-Demethylnobiletin

TN1244

Synonym:

Target: LDL, NF-κB, Integrin, Lipoxygenase, DNA/RNA Synthesis

gamma-Mangostin

T4S1637

Synonym: Normangostin

Target: Others, 5-HT Receptor

Columbin

T4S0590

Synonym:

Target: Phospholipase, COX, Parasite

Folinic acid

T24403

Synonym: HSDB 6544,Leucovorin

Target: Endogenous Metabolite, Antifolate

Rotundic acid

T5S0506

Synonym: Rutundic acid

Target: Apoptosis, Others, p38 MAPK, Akt, mTOR

3-O-Methylgallic acid

TN1237

Synonym: 3,4-Dihydroxy-5-methoxybenzoic acid

Target: Apoptosis, NF-κB, OCT, DNA/RNA Synthesis, STAT

Target: Apoptosis, BCL

3'-Hydroxypterostilbene

T2S2382

Synonym: 3'-HPT

Target: Apoptosis, Autophagy

Silibinin

T1660

Synonym: Silibinin A,Silybin,Silymarin I

Target: Reactive Oxygen Species, Autophagy

Brevilin A

T4672

Synonym:

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Dauricine

T6S0119

Synonym:

Target: Apoptosis, Others, NF-κB

9-hydroxy Stearic Acid

Synonym: NSC170364,Aeroplysinin I,NSC 170364,NSC-170364

Neoanhydropodophyllol

Target: TNF, Antifection

Target: Wnt/beta-catenin

Target: BCL, p38 MAPK, ROS, Akt, Caspase, Antifection, p53

6-Acetonyldihydrochelerythrine

TN3152

Synonym:

Target: ERK, BCL, Akt, HIV Protease, PPAR, p53

Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK

4beta-Hydroxywithanolide E

TN3070

Synonym:

Target: PARP, HSP, NF-κB, COX

Synonym: Pedalin,Pedalitin 6-O-glucoside,Glucosyl-6-pedalitin

Target: IL Receptor, NOS

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPK-01138	PLD4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Phospholipase D4 (PLD4) is a newly identified protein expressed in microglia. the expression of PLD4 was located in macrophages in the colon cancer mesenchymal and lymph nodes as shown by immunohistochemical analysis. fu...
TMPK-01079	PLD4 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Phospholipase D4 (PLD4) is a newly identified protein expressed in microglia. the expression of PLD4 was located in macrophages in the colon cancer mesenchymal and lymph nodes as shown by immunohistochemical analysis. fu...
TMPK-00743	LGR-5 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker...
TMPY-02249	FABP6 Protein, Human, Recombinant	Human	E. coli
	Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to t...
TMPY-01344	MAP1D Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Methionine aminopeptidase 1D, also known as MAP1D, is a member of the peptidase M24A family. N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localizatio...
TMPJ-01194	BTNL9 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Butyrophilin-Like Protein 9 (BTNL9) is single-pass type I membrane protein member of the BTN/MOG family that belongs to the immunoglobulin superfamily. BTNL9 consists of two domains: one B30.2/SPRY domain and one Ig-like...
TMPJ-01209	BTNL9 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Butyrophilin-Like Protein 9 (BTNL9) is single-pass type I membrane protein member of the BTN/MOG family that belongs to the immunoglobulin superfamily. BTNL9 consists of two domains: one B30.2/SPRY domain and one Ig-like...
TMPJ-01195	BTNL9 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Butyrophilin-Like Protein 9 (BTNL9) is single-pass type I membrane protein member of the BTN/MOG family that belongs to the immunoglobulin superfamily. BTNL9 consists of two domains: one B30.2/SPRY domain and one Ig-like...
TMPY-00507	UNC5B Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium ...
TMPY-04003	UNC5B Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium ...
TMPY-03285	PPIL1 Protein, Human, Recombinant (His)	Human	E. coli
	PPIL1 is a member of the cyclophilin family. Cyclophilins are well conserved and ubiquitous. Members of cyclophilin family take a significant part in protein folding, immunosuppression by cyclosporin A, and infection of ...
TMPJ-01288	KLF6 Protein, Human, Recombinant	Human	E. coli
	Krueppel-Like Factor 6 (KLF6) belongs to the krueppel C2H2-type zinc-finger protein family. KLF6 contains three C2H2-type zinc fingers and localizes in the nucleus. KLF6 expression is highest in the placenta followed by ...
TMPY-04133	UNC5B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium ...
TMPY-04899	OGN/Osteoglycin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	OGN (Osteoglycin) is a Protein Coding gene. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. It belongs to the small leucine-rich proteoglycan (SLRP) family. The encoded protei...
TMPU-00004	STAT5A Protein, Human, Recombinant (His)	Human	E. coli
	Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. Many studies have indicated a key role of STAT5a in leukemia, breast, colon, head and neck, and prostate canc...
TMPY-04930	Notch 2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of dev...
TMPY-03601	PDRG1 Protein, Human, Recombinant (His)	Human	E. coli
	PDRG1, also known as C2orf126, belongs to the prefoldin subunit beta family. It is predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs. PDRG1 may play a role in chapero...
TMPJ-00694	BRD4 Protein, Human, Recombinant (His & Flag)	Human	E. coli
	Bromodomain-containing protein 4 (BRD4) is a member of the BET class chromatin reader proteins that bind acetylated histones and play a key role in transcriptional regulation and transmission of epigenetic memory. Remain...
TMPY-03172	Argininosuccinate lyase Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established r...
TMPY-04307	GNRH2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	GNRH2 (Gonadotropin-Releasing Hormone 2) is a Protein Coding gene. This gene is a member of the gonadotropin-releasing hormone (GnRH) gene family. Proteins encoded by members of this gene family are proteolytically cleav...
TMPY-01775	AIM2 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	AIM2, Absent In Melanoma 2 is a member of the interferon-inducible HIN-200 protein family that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding domain, senses cytopla...
TMPY-00924	SMAC Protein, Human, Recombinant (His)	Human	E. coli
	Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric p...
TMPY-01762	IGF2BP-2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is a member of the IGF-II mRNA-binding protein (IMP) family. IGF2BP2 is a member of a family of mRNA binding proteins that, collectively, have been shown to b...
TMPY-01890	CLIC4 Protein, Human, Recombinant (His)	Human	E. coli
	Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains oneGST C-terminal domain. CLIC4 is a mem...
TMPY-01249	Cathepsin V Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and t...

PLD4 Protein, Human, Recombinant (His)

TMPK-01138

Species: Human

Expression System: HEK293 Cells

PLD4 Protein, Mouse, Recombinant (His)

TMPK-01079

Species: Mouse

Expression System: HEK293 Cells

LGR-5 Protein, Human, Recombinant (hFc)

TMPK-00743

Species: Human

Expression System: HEK293 Cells

FABP6 Protein, Human, Recombinant

TMPY-02249

Species: Human

Expression System: E. coli

MAP1D Protein, Human, Recombinant (His)

TMPY-01344

Species: Human

Expression System: Baculovirus Insect Cells

BTNL9 Protein, Human, Recombinant (hFc)

TMPJ-01194

Species: Human

Expression System: HEK293 Cells

BTNL9 Protein, Mouse, Recombinant (hFc)

TMPJ-01209

Species: Mouse

Expression System: HEK293 Cells

BTNL9 Protein, Human, Recombinant (His)

TMPJ-01195

Species: Human

Expression System: HEK293 Cells

UNC5B Protein, Human, Recombinant (hFc)

TMPY-00507

Species: Human

Expression System: HEK293 Cells

UNC5B Protein, Rat, Recombinant (hFc)

TMPY-04003

Species: Rat

Expression System: HEK293 Cells

PPIL1 Protein, Human, Recombinant (His)

TMPY-03285

Species: Human

Expression System: E. coli

KLF6 Protein, Human, Recombinant

TMPJ-01288

Species: Human

Expression System: E. coli

UNC5B Protein, Human, Recombinant (His)

TMPY-04133

Species: Human

Expression System: HEK293 Cells

OGN/Osteoglycin Protein, Human, Recombinant (His)

TMPY-04899

Species: Human

Expression System: HEK293 Cells

STAT5A Protein, Human, Recombinant (His)

TMPU-00004

Species: Human

Expression System: E. coli

Notch 2 Protein, Human, Recombinant (His)

TMPY-04930

Species: Human

Expression System: Baculovirus Insect Cells

PDRG1 Protein, Human, Recombinant (His)

TMPY-03601

Species: Human

Expression System: E. coli

BRD4 Protein, Human, Recombinant (His & Flag)

TMPJ-00694

Species: Human

Expression System: E. coli

Argininosuccinate lyase Protein, Human, Recombinant (His & GST)

TMPY-03172

Species: Human

Expression System: Baculovirus Insect Cells

GNRH2 Protein, Human, Recombinant (hFc)

TMPY-04307

Species: Human

Expression System: HEK293 Cells

AIM2 Protein, Human, Recombinant (GST)

TMPY-01775

Species: Human

Expression System: Baculovirus Insect Cells

SMAC Protein, Human, Recombinant (His)

TMPY-00924

Species: Human

Expression System: E. coli

IGF2BP-2 Protein, Human, Recombinant (His & GST)

TMPY-01762

Species: Human

Expression System: Baculovirus Insect Cells

CLIC4 Protein, Human, Recombinant (His)

TMPY-01890

Species: Human

Expression System: E. coli

Cathepsin V Protein, Human, Recombinant (His)

TMPY-01249

Species: Human

Expression System: HEK293 Cells

カタログ番号	製品名
L2194	Anti-Colorectal Cancer Compound Library	1545 compounds
	1545 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening.
L6740	Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library	382 compounds
	A collection of 382 TCM monomers with anti-colorectal activity. An effective tool for drug development and pharmacological studies.

ライブラリー

Anti-Colorectal Cancer Compound Library

L2194

Compounds: 1545

Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library

L6740

Compounds: 382